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MAPK signaling pathway
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.

125467750 (EFNA4-EFNA3), 1435 (CSF1), 1942 (EFNA1), 1943 (EFNA2), 1944 (EFNA3), 1945 (EFNA4), 1946 (EFNA5), 1950 (EGF), 2069 (EREG), 2246 (FGF1), 2247 (FGF2), 2248 (FGF3), 2249 (FGF4), 2250 (FGF5), 2251 (FGF6), 2252 (FGF7), 2253 (FGF8), 2254 (FGF9), 2255 (FGF10), 2277 (VEGFD), 2323 (FLT3LG), 26281 (FGF20), 26291 (FGF21), 2668 (GDNF), 27006 (FGF22), 284 (ANGPT1), 285 (ANGPT2), 3082 (HGF), 3479 (IGF1), 3481 (IGF2), 3630 (INS), 374 (AREG), 4254 (KITLG), 4803 (NGF), 4902 (NRTN), 4908 (NTF3), 4909 (NTF4), 51378 (ANGPT4), 5154 (PDGFA), 5155 (PDGFB), 5228 (PGF), 56034 (PDGFC), 5623 (PSPN), 627 (BDNF), 7039 (TGFA), 7422 (VEGFA), 7423 (VEGFB), 7424 (VEGFC), 80310 (PDGFD), 8074 (FGF23), 8817 (FGF18), 8822 (FGF17), 8823 (FGF16), 9048 (ARTN), 9965 (FGF19)7124 (TNF)3552 (IL1A), 3553 (IL1B)356 (FASLG)7040 (TGFB1), 7042 (TGFB2), 7043 (TGFB3)929 (CD14)7046 (TGFBR1), 7048 (TGFBR2)355 (FAS)3554 (IL1R1), 3556 (IL1RAP)7132 (TNFRSF1A)1436 (CSF1R), 1956 (EGFR), 1969 (EPHA2), 2064 (ERBB2), 2065 (ERBB3), 2066 (ERBB4), 2260 (FGFR1), 2261 (FGFR3), 2263 (FGFR2), 2264 (FGFR4), 2321 (FLT1), 2322 (FLT3), 2324 (FLT4), 3480 (IGF1R), 3643 (INSR), 3791 (KDR), 3815 (KIT), 4233 (MET), 4804 (NGFR), 4914 (NTRK1), 4915 (NTRK2), 5156 (PDGFRA), 5159 (PDGFRB), 5979 (RET), 7010 (TEK)10368 (CACNG3), 10369 (CACNG2), 27091 (CACNG5), 27092 (CACNG4), 55799 (CACNA2D3), 59283 (CACNG8), 59284 (CACNG7), 59285 (CACNG6), 773 (CACNA1A), 774 (CACNA1B), 775 (CACNA1C), 776 (CACNA1D), 777 (CACNA1E), 778 (CACNA1F), 779 (CACNA1S), 781 (CACNA2D1), 782 (CACNB1), 783 (CACNB2), 784 (CACNB3), 785 (CACNB4), 786 (CACNG1), 8911 (CACNA1I), 8912 (CACNA1H), 8913 (CACNA1G), 9254 (CACNA2D2), 93589 (CACNA2D4)2885 (GRB2)2768 (GNA12), 55970 (GNG12)8717 (TRADD)4615 (MYD88)3654 (IRAK1), 51135 (IRAK4)6654 (SOS1), 6655 (SOS2)5922 (RASA2)5923 (RASGRF1), 5924 (RASGRF2)10125 (RASGRP1), 10235 (RASGRP2), 115727 (RASGRP4), 25780 (RASGRP3)22800 (RRAS2), 22808 (MRAS), 3265 (HRAS), 3845 (KRAS), 4893 (NRAS), 6237 (RRAS)4763 (NF1)5921 (RASA1)9693 (RAPGEF2)5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG)5566 (PRKACA), 5567 (PRKACB), 5568 (PRKACG)5906 (RAP1A), 5908 (RAP1B)369 (ARAF)673 (BRAF)5894 (RAF1)5604 (MAP2K1)5605 (MAP2K2)8649 (LAMTOR3)5594 (MAPK1), 5595 (MAPK3)1845 (DUSP3), 5778 (PTPN7), 5801 (PTPRR), 84867 (PTPN5)11221 (DUSP10), 1843 (DUSP1), 1844 (DUSP2), 1846 (DUSP4), 1847 (DUSP5), 1848 (DUSP6), 1849 (DUSP7), 1850 (DUSP8), 1852 (DUSP9), 80824 (DUSP16)9020 (MAP3K14)1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG)4790 (NFKB1), 4791 (NFKB2), 5970 (RELA), 5971 (RELB)4137 (MAPT)3925 (STMN1)100137049 (PLA2G4B), 123745 (PLA2G4E), 255189 (PLA2G4F), 283748 (PLA2G4D), 5321 (PLA2G4A), 8605 (PLA2G4C), 8681 (JMJD7-PLA2G4B)2872 (MKNK2), 8569 (MKNK1)27330 (RPS6KA6), 6195 (RPS6KA1), 6196 (RPS6KA2), 6197 (RPS6KA3)468 (ATF4)2002 (ELK1)2005 (ELK4)4609 (MYC)4149 (MAX)6722 (SRF)2353 (FOS)7189 (TRAF6)10912 (GADD45G), 1647 (GADD45A), 4616 (GADD45B)5879 (RAC1), 5880 (RAC2), 5881 (RAC3), 998 (CDC42)836 (CASP3)7186 (TRAF2)1616 (DAXX)10454 (TAB1)23118 (TAB2)51295 (ECSIT)8491 (MAP4K3)9448 (MAP4K4)11184 (MAP4K1)5058 (PAK1), 5062 (PAK2)6788 (STK3), 6789 (STK4)5871 (MAP4K2)1326 (MAP3K8)4214 (MAP3K1)4296 (MAP3K11)10746 (MAP3K2), 4215 (MAP3K3)4293 (MAP3K9), 4294 (MAP3K10), 84451 (MAP3K21)7786 (MAP3K12), 9175 (MAP3K13)51776 (MAP3K20)9064 (MAP3K6)4217 (MAP3K5)6885 (MAP3K7)5495 (PPM1B)4216 (MAP3K4)51347 (TAOK3), 57551 (TAOK1), 9344 (TAOK2)2316 (FLNA)408 (ARRB1), 409 (ARRB2)6416 (MAP2K4)5609 (MAP2K7)10000 (AKT3), 207 (AKT1), 208 (AKT2)5494 (PPM1A)5606 (MAP2K3)5608 (MAP2K6)5536 (PPP5C)5607 (MAP2K5)23162 (MAPK8IP3)1398 (CRK), 1399 (CRKL)3303 (HSPA1A), 3304 (HSPA1B), 3305 (HSPA1L), 3310 (HSPA6), 3312 (HSPA8)2122 (MECOM)5599 (MAPK8), 5601 (MAPK9), 5602 (MAPK10)23542 (MAPK8IP2), 9479 (MAPK8IP1)5530 (PPP3CA), 5532 (PPP3CB), 5533 (PPP3CC), 5534 (PPP3R1), 5535 (PPP3R2)4772 (NFATC1)4775 (NFATC3)2353 (FOS), 3725 (JUN)3727 (JUND)1845 (DUSP3), 5778 (PTPN7), 5801 (PTPRR), 84867 (PTPN5)11221 (DUSP10), 1844 (DUSP2), 1846 (DUSP4), 1847 (DUSP5), 1849 (DUSP7), 1850 (DUSP8), 1852 (DUSP9), 80824 (DUSP16)1432 (MAPK14), 5600 (MAPK11), 5603 (MAPK13), 6300 (MAPK12)1386 (ATF2)2002 (ELK1)7157 (TP53)2005 (ELK4)1649 (DDIT3)4149 (MAX)4208 (MEF2C)8550 (MAPKAPK5)7867 (MAPKAPK3), 9261 (MAPKAPK2)8986 (RPS6KA4), 9252 (RPS6KA5)994 (CDC25B)3315 (HSPB1)468 (ATF4)51701 (NLK)5598 (MAPK7)3164 (NR4A1)


产品列表
    货号
    产品
    反应
    应用
  • CAC1A Rabbit pAb
    Human,Mouse,Rat
    IHC,IF
  • Cav2.2 Rabbit pAb
    Human,Rat,Mouse
    IHC,IF
  • Cav1.2 Rabbit pAb
    Human,Rat,Mouse
    IHC,IF
  • Cav (pan) α1 Rabbit pAb
    Human,Rat,Mouse
    IHC,IF
  • CACNA1C Rabbit pAb
    Human,Rat,Mouse
    WB,ELISA
  • CACNA1C (Phospho Ser1981) Rabbit pAb
    Human,Mouse,Rat
    WB
  • Cav1.3 Rabbit pAb
    Human,Rat,Mouse
    IHC,IF
  • CAC1E Rabbit pAb
    Human,Mouse,Rat
    IHC,IF
  • CACNA1F (PT0769R) PT® Rabbit mAb
    Human
    WB,Flow Cyt
  • CAC1F Rabbit pAb
    Human,Mouse
    WB,ELISA
  • 1
  • 2
  • 3
  • 4
  • 152