This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009],
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Catalytic activity:ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.,Function:Activates acetate so that it can be used for lipid synthesis or for energy generation.,similarity:Belongs to the ATP-dependent AMP-binding enzyme family.,subunit:Monomer.,