The antiserum was produced against synthesized peptide derived from human V-ATPase D1. AA range:221-270

V-ATPase D1 Polyclonal Antibody detects endogenous levels of V-ATPase D1 protein.

ATP6V0D1

V-type proton ATPase subunit d 1

ATP6V0D1 ;
ATP6D ;
VPATPD ;
V-type proton ATPase subunit d 1 ;
V-ATPase subunit d 1 ;
32 kDa accessory protein ;
V-ATPase 40 kDa accessory protein ;
V-ATPase AC39 subunit ;
p39 ;
Vacuolar proton pump subunit d 1

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [pro

Function:Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis.,similarity:Belongs to the V-ATPase V0D/AC39 subunit family.,subunit:V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).,tissue specificity:Ubiquitous.,

Membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein . Localizes to centrosome and the base of the cilium. .

Ubiquitous.

>>Oxidative phosphorylation ;
>>Metabolic pathways ;
>>Lysosome ;
>>Phagosome ;
>>Synaptic vesicle cycle ;
>>Collecting duct acid secretion ;
>>Vibrio cholerae infection ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Tuberculosis ;
>>Human papillomavirus infection ;
>>Viral carcinogenesis ;
>>Rheumatoid arthritis