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Glutamatergic synapse
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synaptic cleft, glutamate acts on postsynaptic ionotropic glutamate receptors (iGluRs) to mediate fast excitatory synaptic transmission. Glutamate can also act on metabotropic glutamate receptors (mGluRs) and exert a variety of modulatory effects through their coupling to G proteins and the subsequent recruitment of second messenger systems. Presynaptically localized Group II and Group III mGluRs are thought to represent the classical inhibitory autoreceptor mechanism that suppresses excess glutamate release. After its action on these receptors, glutamate can be removed from the synaptic cleft by EAATs located either on the presynaptic terminal, neighboring glial cells, or the postsynaptic neuron. In glia, glutamate is converted to glutamine, which is then transported back to the presynaptic terminal and converted back to glutamate.
产品列表
    货号
    产品
    反应
    应用
  • SLC38A1 Rabbit pAb
    Human,Mouse,Rat
    WB
  • SNAT2 Rabbit pAb
    Human,Rat,Mouse,
    WB,ELISA,IHC
  • GLS2 Rabbit pAb
    Human,Mouse,Rat
    WB
  • Glutaminase C (PT0168R) PT® Rabbit mAb
    Human,Mouse,Rat,
    WB,IHC,IF,IP,ELISA
  • GLSK Rabbit pAb
    Human,Mouse,Rat
    WB
  • VGLU2 Rabbit pAb
    Human,Mouse,Rat
    WB,ELISA
  • VGLU1 Rabbit pAb
    Human,Mouse,Rat
    WB
  • GluR-5 Rabbit pAb
    Human,Mouse,Rat
    WB,IHC,IF,ELISA
  • Total GluR-5 Cell-Based Colorimetric ELISA Kit
    Human,Mouse,Rat
    ELISA
  • GRIK2 (GluR6) Rabbit pAb
    Human
    IHC,IF
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  • 2
  • 3
  • 4
  • 21