The specific immunogen used to produce this antibody is proprietary information.

Endogenous

KEAP1 INRF2 KIAA0132 KLHL19

Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19)

KEAP1 ;
INRF2 ;
KIAA0132 ;
KLHL19 ;
Kelch-like ECH-associated protein 1 ;
Cytosolic inhibitor of Nrf2 ;
INrf2 ;
Kelch-like protein 19

kelch like ECH associated protein 1 (KEAP1) Homo sapiens This gene encodes a protein containing KELCH-1 like domains , as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq , Jul 2008] ,

Disease:Defects in KEAP1 may be a cause of breast cancer. ,Disease:Defects in KEAP1 may be involved in non small cell lung carcinomas (NSCLC) and lung adenocarcinoma. ,Domain:The Kelch repeats mediate interaction with NF2L2/NRF2 , BPTF and PGAM5. ,enzyme regulation:Ubiquitination and subsequent degradation of PGAM5 is inhibited by oxidative stress and sulforaphane. ,Function:Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome , thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. ,PTM:Ubiquitinated and subject to proteasomal degradation. ,similarity:Contains 1 BACK (BTB/Kelch associated) domain. ,similarity:Contains 1 BTB (POZ) domain. ,similarity:Contains 6 Kelch repeats. ,subcellular location:Shuttles between cytoplasm and nucleus. ,subunit:Homodimer. Interacts with the N-terminal regulatory domain of NF2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1 , CUL3 and RBX1. Interacts with PGAM5. ,tissue specificity:Broadly expressed , with highest levels in skeletal muscle. ,

Cytoplasm , Nucleus

>>Ubiquitin mediated proteolysis ;
>>Parkinson disease ;
>>Pathways in cancer ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Hepatocellular carcinoma ;
>>Fluid shear stress and atherosclerosis