Synthesized peptide derived from part region of human protein. AA range 1-50

DGAT2 Polyclonal Antibody detects endogenous levels of protein.

DGAT2 HMFN1045 UNQ738/PRO1433

Diacylglycerol O-acyltransferase 2 (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (Diglyceride acyltransferase 2)

This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Catalytic activity:Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.,enzyme regulation:Inhibited by niacin.,Function:Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation.,pathway:Glycerolipid metabolism; triacylglycerol biosynthesis.,similarity:Belongs to the diacylglycerol acyltransferase family.,tissue specificity:Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammaray gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin.,

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Lipid droplet . Cytoplasm, perinuclear region .

Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin.

>>Glycerolipid metabolism ;
>>Metabolic pathways ;
>>Fat digestion and absorption