Synthesized peptide derived from part region of human protein

ELP3 Polyclonal Antibody detects endogenous levels of protein.

ELP3

Elongator complex protein 3 (hELP3) (EC 2.3.1.48)

ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009],

Catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,cofactor:Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.,Function:Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity.,similarity:Belongs to the ELP3 family.,similarity:Contains 1 N-acetyltransferase domain.,subunit:Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. IKBKAP/ELP1, STIP1/ELP2 and ELP3 form the Elongator core complex. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with IKBKAP/ELP1.,

Cytoplasm . Nucleus .; [Isoform 1]: Nucleus .; [Isoform 2]: Cytoplasm . Nucleus .

Expressed in the cerebellum and spinal motor neurons.