SYT1/SYT2

cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.,domain:The first C2 domain mediates Ca(2+)-dependent phospholipid binding.,domain:The second C2 domain mediates interaction with SV2A and STN2.,function:May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subcellular location:Synaptic vesicles and chromaffin granules.,subunit:Homotetramer (Probable). Interacts with SCAMP5, STN2, SV2A, SV2B, SV2C and RIMS1. Forms a complex with SV2B, syntaxin 1 and SNAP25.,

regulation of neurotransmitter levels, generation of a signal involved in cell-cell signaling, detection of calcium ion,protein complex assembly, neurotransmitter transport, cell-cell signaling, synaptic transmission, neurotransmitter secretion, detection of chemical stimulus, response to inorganic substance, response to metal ion, regulation of exocytosis, transmission of nerve impulse, secretion by cell, macromolecular complex subunit organization, secretion,neurological system process, regulation of secretion, protein oligomerization, protein homooligomerization, response to calcium ion, detection of stimulus, regulation of cellular localization, regulation of vesicle-mediated transport,macromolecular complex assembly, protein complex biogenesis,

Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane ; Single-pass membrane protein . Cytoplasm .

Expressed in melanocytes (PubMed:23999003).