Claudin 3 (ABT-CLD3) Mouse mAb
-YM4921
主要信息
Target
Claudin 3
Host Species
Mouse
Reactivity
Human
Applications
WB, IHC, IF, ELISA
MW
23kD (Calculated)
20kD (Observed)
Conjugate/Modification
Unmodified
货号: YM4921
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
This antibody detects endogenous levels of Claudin 3 protein.
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
23kD
实测条带
20kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT-CLD3
同种型
Mouse IgG1/Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human Claudin 3 AA range: 150-220
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特异性:
This antibody detects endogenous levels of Claudin 3 protein.
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基因名称:
CLDN3 C7orf1 CPETR2
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蛋白名称:
Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE-R 2) (CPE-receptor 2) (Rat ventral prostate.1 protein homolog) (hRVP1)
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背景:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets , forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet , with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene , a member of the claudin family , is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin , and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq , Jul 2008] ,
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功能:
Disease:Haploinsufficiency of CLDN3 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) , a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23. ,Function:Plays a major role in tight junction-specific obliteration of the intercellular space , through calcium-independent cell-adhesion activity. ,similarity:Belongs to the claudin family. ,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1 , TJP2/ZO-2 and TJP3/ZO-3. ,
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细胞定位:
Membranous
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组织表达:
研究领域:
>>Cell adhesion molecules ;
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
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信号通路
文献引用（{{totalcount}}）
货号: YM4921
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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