Endogenous

CYBB

Cytochrome b-245 heavy chain

CYBB ;
NOX2 ;
Cytochrome b-245 heavy chain ;
CGD91-phox ;
Cytochrome b ;
558 ;
subunit beta ;
Cytochrome b558 subunit beta ;
Heme-binding membrane glycoprotein gp91phox ;
NADPH oxidase 2Neutrophil cytochrome b 91 kDa polypeptide ;
Superoxide-generating NADPH oxidase heavy chain subunit ;
gp91-1 ;
gp91-phox ;
p22 phagocyte B-cytochrome

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008],

cofactor:FAD.,Disease:Defects in CYBB are a cause of chronic granulomatous disease X-linked (XCGD) [MIM:306400]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.,Function:Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.,online information:CYBB deficiency database,PTM:Glycosylated.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 ferric oxidoreductase domain.,subunit:Composed of a heavy chain (beta) and a light chain (alpha).,

Membranous

Detected in neutrophils (at protein level).

>>HIF-1 signaling pathway ;
>>Phagosome ;
>>Ferroptosis ;
>>Necroptosis ;
>>Neutrophil extracellular trap formation ;
>>NOD-like receptor signaling pathway ;
>>Leukocyte transendothelial migration ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Alzheimer disease ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Leishmaniasis ;
>>Coronavirus disease - COVID-19 ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis