Endogenous

CAT

Catalase

CAT ;
Catalase

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009],

Catalytic activity:2 H(2)O(2) = O(2) + 2 H(2)O.,cofactor:Heme group.,cofactor:NADP.,Disease:Defects in CAT are the cause of acatalasia (ACATLAS) [MIM:115500]; also known as acatalasemia. This disease is characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions.,Function:Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.,online information:Catalase entry,PTM:The N-terminus is blocked.,similarity:Belongs to the catalase family.,subunit:Homotetramer.,

Cytoplasm

Brain,Cajal-Retzius cell,Erythrocyte,Eye,Fibroblast,Kidney,Liver,Placenta,Platelet,Skin,Uterus,

>>Tryptophan metabolism ;
>>Glyoxylate and dicarboxylate metabolism ;
>>Metabolic pathways ;
>>Carbon metabolism ;
>>FoxO signaling pathway ;
>>Peroxisome ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Chemical carcinogenesis - reactive oxygen species