Synthesized peptide derived from human protein . at AA range: 40-120

ITA9 Polyclonal Antibody detects endogenous levels of protein.

ITGA9

Integrin alpha-9 (Integrin alpha-RLC)

integrin subunit alpha 9(ITGA9) Homo sapiens This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008],

Function:Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.,induction:Up-regulated in small cell lung cancers (SCLC).,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-9 associates with beta-1.,tissue specificity:In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.,

Membrane ; Single-pass type I membrane protein .

In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.

>>PI3K-Akt signaling pathway ;
>>Focal adhesion ;
>>ECM-receptor interaction ;
>>Cell adhesion molecules ;
>>Regulation of actin cytoskeleton ;
>>Human papillomavirus infection ;
>>Hypertrophic cardiomyopathy ;
>>Arrhythmogenic right ventricular cardiomyopathy ;
>>Dilated cardiomyopathy