Synthesized peptide derived from human SPTC2 AA range: 273-323

This antibody detects endogenous levels of SPTC2 at Human/Mouse

SPTLC2 KIAA0526 LCB2

SPTC2

Serine palmitoyltransferase 2 ;
Long chain base biosynthesis protein 2 ;
LCB 2 ;
Long chain base biosynthesis protein 2a ;
LCB2a ;
Serine-palmitoyl-CoA transferase 2 ;
SPT 2 ;

This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011],

Catalytic activity:Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2).,cofactor:Pyridoxal phosphate.,pathway:Lipid metabolism; sphingolipid metabolism.,similarity:Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.,subunit:SPTLC1, SPTLC2 and SPTLC3 may encode subunits of the enzyme.,tissue specificity:Widely expressed.,

Endoplasmic reticulum membrane ; Single-pass membrane protein .

Widely expressed.

>>Sphingolipid metabolism ;
>>Metabolic pathways ;
>>Sphingolipid signaling pathway