Synthesized peptide derived from IP3R-I . at AA range: 1700-1780

IP3R-I Polyclonal Antibody detects endogenous levels of IP3R-I protein.

ITPR1

Inositol 1,4,5-trisphosphate receptor type 1

ITPR1 ;
INSP3R1 ;
Inositol 1,4,5-trisphosphate receptor type 1 ;
IP3 receptor isoform 1 ;
IP3R 1 ;
InsP3R1 ;
Type 1 inositol 1,4,5-trisphosphate receptor ;
Type 1 InsP3 receptor

This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009],

Alternative products:There is a combination of three alternatively spliced domains at site SI, SIII and site SII (A and C). Experimental confirmation may be lacking for some isoforms,Disease:Defects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.,Domain:The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.,Function:Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.,miscellaneous:Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.,PTM:Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels.,PTM:Phosphorylated on tyrosine residues.,similarity:Belongs to the InsP3 receptor family.,similarity:Contains 5 MIR domains.,subunit:Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with AHCYL1 (By similarity). Interacts with MRVI1.,tissue specificity:Widely expressed.,

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Endoplasmic reticulum and secretory granules (By similarity). .

Widely expressed.

>>Calcium signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>Phosphatidylinositol signaling system ;
>>Oocyte meiosis ;
>>Autophagy - animal ;
>>Apoptosis ;
>>Cellular senescence ;
>>Vascular smooth muscle contraction ;
>>Apelin signaling pathway ;
>>Gap junction ;
>>Platelet activation ;
>>NOD-like receptor signaling pathway ;
>>C-type lectin receptor signaling pathway ;
>>Circadian entrainment ;
>>Long-term potentiation ;
>>Retrograde endocannabinoid signaling ;
>>Glutamatergic synapse ;
>>Cholinergic synapse ;
>>Serotonergic synapse ;
>>Dopaminergic synapse ;
>>Long-term depression ;
>>Inflammatory mediator regulation of TRP channels ;
>>GnRH signaling pathway ;
>>Estrogen signaling pathway ;
>>Thyroid hormone synthesis ;
>>Oxytocin signaling pathway ;
>>Glucagon signaling pathway ;
>>Renin secretion ;
>>Aldosterone synthesis and secretion ;
>>Cortisol synthesis and secretion ;
>>Parathyroid hormone synthesis, secretion and action ;
>>GnRH secretion ;
>>Cushing syndrome ;
>>Growth hormone synthesis, secretion and action ;
>>Salivary secretion ;
>>Gastric acid secretion ;
>>Pancreatic secretion ;
>>Alzheimer disease ;
>>Parkinson disease ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis ;
>>Human cytomegalovirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Proteoglycans in cancer ;
>>Lipid and atherosclerosis