Recombiant protein AA range: 35-314

This antibody detects endogenous levels of CEA protein.

CEACAM5 CEA

Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e)

Carcinoembryonic antigen antibody ;
Carcinoembryonic antigen-related cell adhesion molecule 5 antibody ;
CD66e antibody ;
CEA antibody ;
Ceacam5 antibody ;
CEAM5_HUMAN antibody ;
DKFZp781M2392 antibody ;
Meconium antigen 100 antibody ;
OTTHUMP00000199032 antibody ;
OTTHUMP00000199033 antibody ;
OTTHUMP00000199034 antibody ;

This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],

Function:Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.,PTM:Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.,similarity:Belongs to the immunoglobulin superfamily. CEA family.,similarity:Contains 7 Ig-like (immunoglobulin-like) domains.,subunit:Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.,tissue specificity:Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.,

Cytoplasmic, Membranous

Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.