GRIN1

Glutamate [NMDA] receptor subunit zeta-1 ;
N-methyl-D-aspartate receptor subunit NR1 ;
NMD-R1 ;

function:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.,online information:NMDA receptor entry,PTM:NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subcellular location:Enriched in post-synaptic plasma membrane and post-synaptic densities.,subunit:Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ.,

conditioned taste aversion, startle response, suckling behavior, response to amphetamine, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, ion transport, cation transport, calcium ion transport, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, cell surface receptor linked signal transduction, glutamate signaling pathway, cell-cell signaling, synaptic transmission, nerve-nerve synaptic transmission, sensory perception, behavior, learning or memory, learning, memory, long-term memory,mating behavior, mating, locomotory behavior, feeding behavior, visual behavior, chemosensory behavior, associative learning, adult locomotory behavior, olfactory learning, visual learning, response to radiation, response to light stimulus, response to abiotic stimulus, response to endogenous stimulus, positive regulation of biosynthetic process,response to organic substance, response to organic nitrogen, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, regulation of cell morphogenesis involved in differentiation, regulation of cell death, positive regulation of cell death, regulation of neuron projection development, response to organic cyclic substance, response to isoquinoline alkaloid, response to amine stimulus, di-, tri-valent inorganic cation transport, reproductive behavior, transmission of nerve impulse,sensory perception of pain, cellular homeostasis, telencephalon development, pallium development, pons development, hindbrain maturation, pons maturation, central nervous system maturation, developmental maturation,cerebral cortex development, metencephalon development, regulation of cell morphogenesis, metal ion transport,cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis, adult behavior, forebrain development,hindbrain development, positive regulation of cellular biosynthetic process, regulation of cell projection organization,regulation of neurological system process, regulation of response to external stimulus, negative regulation of response to external stimulus, multicellular organism reproduction, reproductive behavior in a multicellular organism,social behavior, ionotropic glutamate receptor signaling pathway, synaptic transmission, glutamatergic, olfactory behavior, regulation of membrane potential, homeostatic process, regulation of apoptosis, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death, response to morphine, response to alkaloid, regulation of neuron apoptosis, negative regulation of neuron apoptosis, regulation of respiratory gaseous exchange, regulation of system process, regulation of cellular component biogenesis, regulation of transcription, response to ethanol,regulation of neuron differentiation, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of synaptic plasticity, regulation of neuronal synaptic plasticity, regulation of long-term neuronal synaptic plasticity, negative regulation of response to stimulus,reproductive process in a multicellular organism, regulation of dendrite morphogenesis, chemical homeostasis,regulation of neurogenesis, regulation of axonogenesis, regulation of dendrite development, ion homeostasis,regulation of synapse structure and activity, regulation of synaptic transmission, regulation of synapse organization,neurological system process, cognition, neuromuscular process, positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, behavioral interaction between organisms, membrane depolarization, regulation of nervous system development, regulation of synaptogenesis, regulation of transmission of nerve impulse, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis, regulation of postsynaptic membrane potential, regulation of excitatory postsynaptic membrane potential, prepulse inhibition, male mating behavior, regulation of cell development, negative regulation of cell death,

Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane . Cell junction, synapse, postsynaptic density . Enriched in postsynaptic plasma membrane and postsynaptic densities. .