NFIL3

Nuclear factor interleukin-3-regulated protein ;
E4 promoter-binding protein 4 ;
Interleukin-3 promoter transcriptional activator ;
Interleukin-3-binding protein 1 ;
Transcriptional activator NF-IL3A ;

function:Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death.,induction:Up-regulated by PHA or TPA.,similarity:Belongs to the bZIP family. NFIL3 subfamily.,similarity:Contains 1 bZIP domain.,subunit:Homodimer. Binds DNA as a dimer. Interacts with DR1. Interacts with PER2 and CRY2.,tissue specificity:Expressed in bladder stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and muscle.,

transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, transcription from RNA polymerase II promoter, immune response, RNA biosynthetic process, regulation of transcription, rhythmic process,regulation of RNA metabolic process,

Nucleus .

Expressed in bladder stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and muscle.