Synthesized peptide derived from human Insulin AA range: 25-110

The antibody can specifically recognize human Insulin protein.

INS

Insulin [Cleaved into: Insulin B chain; Insulin A chain]

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010],

Disease:Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].,Function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.,Function:Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.,Function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.,mass spectrometry: PubMed:12586351; PubMed:15359740,online information:Clinical information on Eli Lilly insulin products,online information:Insulin entry,online information:Insulin-like growth factor 2 entry,online information:Protein of the 20th century - Issue 9 of April 2001,pharmaceutical:Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.,similarity:Belongs to the insulin family.,subunit:Heterodimer of a B chain and an A chain linked by two disulfide bonds.,

Cytoplasmic

Blood,Liver,Muscle,Pancreas,

>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>HIF-1 signaling pathway ;
>>FoxO signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Oocyte meiosis ;
>>Autophagy - animal ;
>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Regulation of actin cytoskeleton ;
>>Insulin signaling pathway ;
>>Insulin secretion ;
>>Ovarian steroidogenesis ;
>>Progesterone-mediated oocyte maturation ;
>>Prolactin signaling pathway ;
>>Regulation of lipolysis in adipocytes ;
>>Type II diabetes mellitus ;
>>Insulin resistance ;
>>Non-alcoholic fatty liver disease ;
>>Type I diabetes mellitus ;
>>Maturity onset diabetes of the young ;
>>Aldosterone-regulated sodium reabsorption ;
>>Alzheimer disease ;
>>Prostate cancer ;
>>Diabetic cardiomyopathy