联系我们

400-8787-807

快速订购
货号: YM6156
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

加入购物车

已收藏

收藏

定制服务咨询
主要信息
Target

CD45

Host Species

Mouse

Reactivity

Human,

Applications

IHC, ELISA

MW

200kD (Observed)

Conjugate/Modification

Unmodified

详细信息
推荐稀释比
IHC 1:200-400; ELISA 1:500-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
The antibody can specifically recognize human CD45 protein, including CD45RA, CD45RB and CD45RO.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
实测条带
200kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT-CD45
同种型
IgG2b,Kappa
相关产品
Secondary Antibodies
HRP* Goat Anti Mouse IgG(H+L)
RS0001

预览→

Secondary Antibodies
HRP* Goat Anti Rabbit IgG(H+L)
RS0002

预览→

Primary Antibodies
β-actin (PTR2364) mouse mAb
YM3028

预览→

Primary Antibodies
GAPDH (PTR2304) mouse mAb
YM3029

预览→

抗原&靶点信息
免疫原:
Synthesized peptide derived from human CD45 (LCA) AA range: 500-600
展开内容
特异性:
The antibody can specifically recognize human CD45 protein, including CD45RA, CD45RB and CD45RO.
展开内容
基因名称:
PTPRC CD45
展开内容
蛋白名称:
Receptor-type tyrosine-protein phosphatase C (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)
展开内容
数据库链接:
Organism 基因 ID SwissProt
Human 5788; P08575-3;
背景:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which enc
功能:
Alternative products:At least 8 isoforms are produced,Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,Disease:Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+)SCID) [MIM:608971]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.,Disease:Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.,Domain:The first PTPase domain interacts with SKAP1.,Function:Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits an dephosphorylates SKAP1 and FYN.,online information:CD45 entry,online information:PTPRC mutation db,PTM:Heavily N- and O-glycosylated.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 tyrosine-protein phosphatase domains.,subunit:Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1.,
展开内容
细胞定位:
Membranous
展开内容
组织表达:
Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.
展开内容
研究领域:
>>Cell adhesion molecules ;
>>T cell receptor signaling pathway ;
>>Fc gamma R-mediated phagocytosis ;
>>Salmonella infection ;
>>Primary immunodeficiency
展开内容
货号: YM6156
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

加入购物车

已收藏

收藏

定制服务咨询

Toggle night Mode

{{pinfoXq.title || ''}}

Catalog: {{pinfoXq.catalog || ''}}
Filter:

All

{{item.name}}

{{pinfo.title}}
-{{pinfo.catalog}}

筛选器:

{{item.descr}}

主要信息
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
查看产品详情
产品 {{index}}/{{pcount}}
上一个产品
下一个产品

{{pvTitle}}

滚轮缩放图片
{{pvDescr}}