Mast cell tryptase (ABT-MCT) Mouse mAb
-YM6194
主要信息
Target
Mast cell tryptase
Host Species
Mouse
Reactivity
Human
Applications
IHC, IF, ELISA
MW
30kD (Calculated)
30kD (Observed)
Conjugate/Modification
Unmodified
货号: YM6194
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
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详细信息
推荐稀释比
IHC 1:200-400; IF 1:50-200; ELISA 1:500-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
The antibody can specifically recognize human Mast cell tryptase protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
30kD
实测条带
30kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT-MCT
同种型
IgG1, Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human Mast cell tryptase AA range: 200-275
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特异性:
The antibody can specifically recognize human Mast cell tryptase protein.
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基因名称:
TPSAB1 TPS1 TPS2 TPSB1
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蛋白名称:
Tryptase alpha/beta-1 (Tryptase-1) (Tryptase I) (Tryptase alpha-1)
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背景:
Tryptases comprise a family of trypsin-like serine proteases , the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers , and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon , which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation , such that the alleles were once thought to represent two separate gene
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功能:
Catalytic activity:Preferential cleavage: Arg-|-Xaa , Lys-|-Xaa , but with more restricted specificity than trypsin. ,Function:Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. ,Function:Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection. ,polymorphism:There are two alleles; beta-II and beta-III which differ by 3 residues. ,similarity:Belongs to the peptidase S1 family. ,similarity:Belongs to the peptidase S1 family. Tryptase subfamily. ,similarity:Contains 1 peptidase S1 domain. ,subcellular location:Released from the secretory granules upon mast cell activation. ,subunit:Homotetramer. ,
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细胞定位:
Cytoplasmic
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研究领域:
>>Influenza A
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货号: YM6194
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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