主要信息
Target
PD1
Host Species
Mouse
Reactivity
Human,
Applications
IHC
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
Ready to use for IHC
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
特异性
The antibody can specifically recognize human PD-1 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
2°C to 8°C/1 year
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT-PD1
同种型
IgG1,Kappa
相关产品
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PD-1 (ABT-PD1) mouse mAb
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Secondary Antibodies
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human PD-1 AA range: 1-100
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特异性:
The antibody can specifically recognize human PD-1 protein.
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基因名称:
PDCD1 PD1
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蛋白名称:
Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
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背景:
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],
功能:
developmental stage:Induced at programmed cell death.,Disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,Function:Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer.,
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细胞定位:
Membranous, Cytoplasmic
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组织表达:
Placenta,Pooled tissue,Uterine cervix,
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研究领域:
>>Cell adhesion molecules ;
>>T cell receptor signaling pathway ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer
>>T cell receptor signaling pathway ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer
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信号通路
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