主要信息
Target
S100A1
Host Species
Mouse
Reactivity
Human, Mouse, Rat,
Applications
IHC
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
Ready to use for IHC
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
特异性
The antibody can specifically recognize human S100A1 protein, and has no cross reaction with S100A4 or S100A6.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
2°C to 8°C/1 year
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT1428
同种型
IgG1,Kappa
相关产品
Primary Antibodies
S-100 α Polyclonal Antibody
YT4197
预览→
ELISA Kits
Total S-100 α Cell-Based Colorimetric ELISA Kit
KA3373C
预览→
抗原&靶点信息
免疫原:
Synthesized peptide derived from human S100A1 AA range: 1-50
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特异性:
The antibody can specifically recognize human S100A1 protein, and has no cross reaction with S100A4 or S100A6.
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基因名称:
S100A1 S100A
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蛋白名称:
S100A1
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别名:
Protein S100-A1 ;
S-100 protein alpha chain ;
S-100 protein subunit alpha ;
S100 calcium-binding protein A1 ;
S-100 protein alpha chain ;
S-100 protein subunit alpha ;
S100 calcium-binding protein A1 ;
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背景:
S100 calcium binding protein A1(S100A1) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008],
功能:
Function:Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain.,tissue specificity:Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.,
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细胞定位:
Nuclear, Cytoplasmic
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组织表达:
Highly prevalent in heart (PubMed:12804600, PubMed:1384693). Also found in lesser quantities in skeletal muscle and brain (PubMed:1384693).
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