Synthesized peptide derived from human CD38 AA range: 200-300

The antibody can specifically recognize human CD38 protein.

CD38

ADP-ribosyl cyclase 1 (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38)

The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],

Catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,developmental stage:Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.,enzyme regulation:ATP inhibits the hydrolyzing activity.,Function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.,online information:CD38 entry,similarity:Belongs to the ADP-ribosyl cyclase family.,tissue specificity:Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.,

Membranous

Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

>>Nicotinate and nicotinamide metabolism ;
>>Metabolic pathways ;
>>Calcium signaling pathway ;
>>Hematopoietic cell lineage ;
>>Oxytocin signaling pathway ;
>>Salivary secretion ;
>>Pancreatic secretion