Synthesized peptide derived from human Galectin 3 AA range: 150-250

The antibody can specifically recognize human Galectin 3 protein.

LGALS3 MAC2

Galectin 3

Galectin-3 ;
Gal-3 ;
35 kDa lectin ;
Carbohydrate-binding protein 35 ;
CBP 35 ;
Galactose-specific lectin 3 ;
Galactoside-binding protein ;
GALBP ;
IgE-binding protein ;
L-31 ;
Laminin-binding protein ;
Lectin L-29 ;
Mac-2 antigen ;

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014],

Function:Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis.,online information:Galectin-3,similarity:Contains 1 galectin domain.,subcellular location:Cytoplasmic in adenomas and carcinomas. May be secreted by a non-classical secretory pathway and associate with the cell surface.,subunit:Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.,tissue specificity:A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages.,

Cytoplasmic, Nuclear

A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.