主要信息
Target
Oct-2
Host Species
Mouse
Reactivity
Human, Mouse,
Applications
IHC
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
Ready to use for IHC
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
特异性
The antibody can specifically recognize human Oct-2 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
2°C to 8°C/1 year
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT211
同种型
IgG2b,Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human Oct-2 AA range: 250-350
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特异性:
The antibody can specifically recognize human Oct-2 protein.
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基因名称:
POU2F2 OCT2 OTF2
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蛋白名称:
Oct-2
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别名:
POU domain, class 2, transcription factor 2 ;
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2 ;
Octamer-binding protein 2 ;
Oct-2 ;
Octamer-binding transcription factor 2 ;
OTF-2 ;
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2 ;
Octamer-binding protein 2 ;
Oct-2 ;
Octamer-binding transcription factor 2 ;
OTF-2 ;
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背景:
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
功能:
Function:Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.,similarity:Belongs to the POU transcription factor family. Class-2 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,subunit:Interacts with NR3C1, AR and PGR.,tissue specificity:Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line Molt-4, but not in the T-cell line BW 5147.,
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细胞定位:
Nuclear
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组织表达:
Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.
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研究领域:
>>Herpes simplex virus 1 infection ;
>>Lipid and atherosclerosis
>>Lipid and atherosclerosis
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