主要信息
Target
Cytokeratin 15
Host Species
Mouse
Reactivity
Human,
Applications
IHC
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
Ready to use for IHC
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
特异性
The antibody can specifically recognize human CK15 protein. In immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections, the antibody specifically labels the squamous epithelial cells and carcinomas, and shows no reaction with glandular epithelial cells.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
2°C to 8°C/1 year
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT058
同种型
IgG1,Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human CK15 AA range: 350-456
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特异性:
The antibody can specifically recognize human CK15 protein. In immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections, the antibody specifically labels the squamous epithelial cells and carcinomas, and shows no reaction with glandular epithelial cells.
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基因名称:
KRT15 KRTB
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蛋白名称:
Cytokeratin-15
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别名:
Keratin, type I cytoskeletal 15 ;
Cytokeratin-15 ;
CK-15 ;
Keratin-15 ;
K15 ;
Cytokeratin-15 ;
CK-15 ;
Keratin-15 ;
K15 ;
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背景:
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008],
功能:
miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins.,tissue specificity:Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.,
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细胞定位:
Cytoplasmic, Membranous
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组织表达:
Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.
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研究领域:
>>Estrogen signaling pathway ;
>>Staphylococcus aureus infection
>>Staphylococcus aureus infection
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