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Neurofilament (ABT208) mouse mAb

-YM6895

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货号: YM6895
规格
价格
货期
数量
200μL
¥3,780.00
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100μL
¥2,300.00
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40μL
¥960.00
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0

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主要信息
Target

NF-L

Host Species

Mouse

Reactivity

Human,

Applications

IHC, ELISA

MW

68kD (Calculated)

68kD (Observed)

Conjugate/Modification

Unmodified

详细信息
推荐稀释比
IHC 1:200-400; ELISA 1:500-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
The antibody can specifically recognize human Neurofilament protein, especilaly NF-L protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
68kD
实测条带
68kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT208
同种型
IgG2b,Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human Neurofilament AA range: 400-543
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特异性:
The antibody can specifically recognize human Neurofilament protein, especilaly NF-L protein.
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基因名称:
NEFL NF68 NFL
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蛋白名称:
Neurofilament
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别名:
Neurofilament light polypeptide ;
NF-L ;
68 kDa neurofilament protein ;
Neurofilament triplet L protein ;
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数据库链接:
Organism 基因 ID SwissProt
Human 4747; P07196;
背景:
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008],
功能:
Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Disease:Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F (CMT1F) [MIM:607734]. CMT1F is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1F is characterized by onset in infancy or childhood (range 1 to 13 years).,Disease:Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 2E (CMT2E) [MIM:607684]. CMT2E is an autosomal dominant form of Charcot-Marie-Tooth disease type 2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.,Domain:The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions.,Function:Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.,miscellaneous:NF-L is the most abundant of the three neurofilament proteins and, as the other nonepithelial intermediate filament proteins, it can form homopolymeric 10-nm filaments.,PTM:O-glycosylated.,similarity:Belongs to the intermediate filament family.,subunit:Interacts with RGNEF.,
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细胞定位:
Cytoplasmic
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组织表达:
Cytoplasmic
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研究领域:
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases
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货号: YM6895
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

加入购物车

已收藏

收藏

定制服务咨询

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