RIP3 (PT0528R) PT® Rabbit mAb
-YM8350
主要信息
Target
RIP3
Host Species
Rabbit
Reactivity
Mouse
Applications
WB, IF, IP, ELISA
MW
50kD (Calculated)
50kD (Observed)
Conjugate/Modification
Unmodified
货号: YM8350
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
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详细信息
推荐稀释比
WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
50kD
实测条带
50kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT0528R
同种型
IgG,Kappa
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抗原&靶点信息
特异性:
Endogenous
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基因名称:
RIPK3 RIP3
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蛋白名称:
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)
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背景:
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008],
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Promotes apoptosis.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex.,tissue specificity:Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.,
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细胞定位:
Cytoplasm, Nucleus
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组织表达:
Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. ; [Isoform 3]: Expression is significantly increased in colon and lung cancers.
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研究领域:
>>Necroptosis ;
>>NOD-like receptor signaling pathway ;
>>Cytosolic DNA-sensing pathway ;
>>TNF signaling pathway ;
>>Salmonella infection
>>NOD-like receptor signaling pathway ;
>>Cytosolic DNA-sensing pathway ;
>>TNF signaling pathway ;
>>Salmonella infection
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信号通路
文献引用（{{totalcount}}）
货号: YM8350
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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