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RAP1B Rabbit pAb
-YN2237
主要信息
Target
RAP1B
Host Species
Rabbit
Reactivity
Human, Rat, Mouse
Applications
WB, ELISA
MW
20kD (Observed)
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
WB 1:500-2000; ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
特异性
RAP1B Polyclonal Antibody detects endogenous levels of protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
20kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human protein . at AA range: 110-190
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特异性:
RAP1B Polyclonal Antibody detects endogenous levels of protein.
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基因名称:
RAP1B OK/SW-cl.11
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蛋白名称:
Ras-related protein Rap-1b (GTP-binding protein smg p21B)
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背景:
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011],
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功能:
enzyme regulation:Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner.,similarity:Belongs to the small GTPase superfamily. Ras family.,subcellular location:May shuttle between plasma membrane and cytosol.,subunit:Interacts with SGSM1, SGSM2 and SGSM3.,
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细胞定位:
Cell membrane . Cytoplasm, cytosol . Cell junction . May shuttle between plasma membrane and cytosol (PubMed:3141412). Presence of KRIT1 and CDH5 is required for its localization to the cell junction (PubMed:20332120). .
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组织表达:
Amygdala,Brain,Chondrosarcoma,Colon adenocarcinoma,Placenta,Platele
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研究领域:
>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>cAMP signaling pathway ;
>>Chemokine signaling pathway ;
>>Focal adhesion ;
>>Platelet activation ;
>>Leukocyte transendothelial migration ;
>>Long-term potentiation ;
>>Neurotrophin signaling pathway ;
>>Cushing syndrome ;
>>Pancreatic secretion ;
>>Renal cell carcinoma ;
>>Lipid and atherosclerosis
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>cAMP signaling pathway ;
>>Chemokine signaling pathway ;
>>Focal adhesion ;
>>Platelet activation ;
>>Leukocyte transendothelial migration ;
>>Long-term potentiation ;
>>Neurotrophin signaling pathway ;
>>Cushing syndrome ;
>>Pancreatic secretion ;
>>Renal cell carcinoma ;
>>Lipid and atherosclerosis
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信号通路
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion Cellular Processes >> Cellular community - eukaryotes >> Adherens junction Organismal Systems >> Immune system >> Platelet activation Organismal Systems >> Immune system >> Leukocyte transendothelial migration Organismal Systems >> Immune system >> Chemokine signaling pathway Organismal Systems >> Nervous system >> Neurotrophin signaling pathway Human Diseases >> Cancer: specific types >> Renal cell carcinoma Environmental Information Processing >> Signal transduction >> MAPK signaling pathway Environmental Information Processing >> Signal transduction >> Ras signaling pathway Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
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