This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008],
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功能:
Function:Inhibitor of Wnt signaling pathway.,PTM:Appears to be not glycosylated.,PTM:Can be proteolytically processed by a furin-like protease.,similarity:Belongs to the dickkopf family.,tissue specificity:Expressed in cerebellum, T-cells, esophagus and lung.,
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细胞定位:
Secreted.
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组织表达:
Expressed in cerebellum, T-cells, esophagus and lung.