The antiserum was produced against synthesized peptide derived from human HLA-DOB. AA range:1-50

HLA-DOβ Polyclonal Antibody detects endogenous levels of HLA-DOβ protein.

HLA-DOB

HLA class II histocompatibility antigen DO beta chain

HLA-DOB ;
HLA class II histocompatibility antigen ;
DO beta chain ;
MHC class II antigen DOB

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],

Function:Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule.,polymorphism:The following alleles of DOB are known: DOB*0101, DOB*0102, DOB*0103 and DOB*0104. The sequence shown is that of DOB*0101.,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain (DOA) and a beta chain (DOB).,

Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

B-cell,

>>Phagosome ;
>>Cell adhesion molecules ;
>>Antigen processing and presentation ;
>>Hematopoietic cell lineage ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>Intestinal immune network for IgA production ;
>>Type I diabetes mellitus ;
>>Leishmaniasis ;
>>Toxoplasmosis ;
>>Staphylococcus aureus infection ;
>>Tuberculosis ;
>>Influenza A ;
>>Human T-cell leukemia virus 1 infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Asthma ;
>>Autoimmune thyroid disease ;
>>Inflammatory bowel disease ;
>>Systemic lupus erythematosus ;
>>Rheumatoid arthritis ;
>>Allograft rejection ;
>>Graft-versus-host disease ;
>>Viral myocarditis