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NMDAε4 Rabbit pAb
-YT3155
主要信息
Target
GRIN2D
Host Species
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Applications
WB, ELISA
MW
170kD (Observed)
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
NMDAε4 Polyclonal Antibody detects endogenous levels of NMDAε4 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
170kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human GRIN2D. AA range:671-720
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特异性:
NMDAε4 Polyclonal Antibody detects endogenous levels of NMDAε4 protein.
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基因名称:
GRIN2D
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蛋白名称:
Glutamate [NMDA] receptor subunit epsilon-4
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别名:
GRIN2D ;
GluN2D ;
NMDAR2D ;
Glutamate [NMDA] receptor subunit epsilon-4 ;
EB11 ;
N-methyl D-aspartate receptor subtype 2D ;
NMDAR2D ;
NR2D
GluN2D ;
NMDAR2D ;
Glutamate [NMDA] receptor subunit epsilon-4 ;
EB11 ;
N-methyl D-aspartate receptor subtype 2D ;
NMDAR2D ;
NR2D
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背景:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010],
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功能:
Function:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B).,
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细胞定位:
Cell membrane ; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
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组织表达:
Brain,Fetal brain,
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研究领域:
>>Calcium signaling pathway ;
>>cAMP signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Circadian entrainment ;
>>Long-term potentiation ;
>>Glutamatergic synapse ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Spinocerebellar ataxia ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Nicotine addiction ;
>>Alcoholism
>>cAMP signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Circadian entrainment ;
>>Long-term potentiation ;
>>Glutamatergic synapse ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Spinocerebellar ataxia ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Nicotine addiction ;
>>Alcoholism
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信号通路
Organismal Systems >> Nervous system >> Glutamatergic synapse Human Diseases >> Neurodegenerative disease >> Alzheimer disease Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia Human Diseases >> Neurodegenerative disease >> Prion disease Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases Environmental Information Processing >> Signal transduction >> Calcium signaling pathway Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
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