RORα Rabbit pAb
-YT4166
主要信息
Target
RORα
Host Species
Rabbit
Reactivity
Human, Monkey
Applications
WB, IHC, IF, ELISA
MW
60kD (Observed)
Conjugate/Modification
Unmodified
货号: YT4166
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
RORα Polyclonal Antibody detects endogenous levels of RORα protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
60kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human RORA. AA range:6-55
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特异性:
RORα Polyclonal Antibody detects endogenous levels of RORα protein.
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基因名称:
RORA
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蛋白名称:
Nuclear receptor ROR-alpha
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别名:
RORA ;
NR1F1 ;
RZRA ;
Nuclear receptor ROR-alpha ;
Nuclear receptor RZR-alpha ;
Nuclear receptor subfamily 1 group F member 1 ;
Retinoid-related orphan receptor-alpha
NR1F1 ;
RZRA ;
Nuclear receptor ROR-alpha ;
Nuclear receptor RZR-alpha ;
Nuclear receptor subfamily 1 group F member 1 ;
Retinoid-related orphan receptor-alpha
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背景:
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014],
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功能:
Function:Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Monomer.,
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细胞定位:
Nucleus .
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组织表达:
Widely expressed in a number of tissues. Expressed in both regulatory T-cells (Treg) and effector T-cells (Teff) (PubMed:18354202, PubMed:7916608). Isoform 4: Highly expressed in the central nervous system, including in the cerebellum (PubMed:29656859).
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研究领域:
>>Th17 cell differentiation ;
>>Circadian rhythm ;
>>Spinocerebellar ataxia ;
>>Inflammatory bowel disease
>>Circadian rhythm ;
>>Spinocerebellar ataxia ;
>>Inflammatory bowel disease
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信号通路
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货号: YT4166
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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