HLA-DMβ Rabbit pAb

-YT6025

2 5
主要信息
Target

HLA-DMβ

Host Species

Rabbit

Reactivity

Human

Applications

IHC, IF, ELISA

Conjugate/Modification

Unmodified

1 / 3
详细信息
推荐稀释比
IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
The antibody detects endogenous HLA-DMβ
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthetic peptide from human protein at AA range: 40-100
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特异性:
The antibody detects endogenous HLA-DMβ
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基因名称:
HLA-DMB DMB RING7
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蛋白名称:
HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB) (Really interesting new gene 7 protein)
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别名:
HLA class II histocompatibility antigen, DM beta chain ;
MHC class II antigen DMB ;
Really interesting new gene 7 protein ;
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数据库链接:
Organism 基因 ID SwissProt
Human 3109; P28068;
Mouse P35737;
背景:
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],
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功能:
Domain:The YXXZ (Tyr-Xaa-Xaa-Zaa, where Zaa is a hydrophobic residue) motif mediates the targeting to the lysosomal compartments.,Function:Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides.,polymorphism:The following alleles of DMB are known: DMB*0101, DMB*0102, DMB*0103, DMB*0104 (DMB3.4), DMB*0105 and DMB*0106. The sequence shown is that of DMB*0101.,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subcellular location:Localizes to late endocytic compartment. Associates with lysosome membranes.,subunit:Heterodimer of an alpha chain (DMA) and a beta chain (DMB).,
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细胞定位:
Late endosome membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein . Localizes to late endocytic compartment. Associates with lysosome membranes.
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组织表达:
Blood,Lymph,Plasma,Spleen,
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研究领域:
>>Phagosome ;
>>Cell adhesion molecules ;
>>Antigen processing and presentation ;
>>Hematopoietic cell lineage ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>Intestinal immune network for IgA production ;
>>Type I diabetes mellitus ;
>>Leishmaniasis ;
>>Toxoplasmosis ;
>>Staphylococcus aureus infection ;
>>Tuberculosis ;
>>Influenza A ;
>>Human T-cell leukemia virus 1 infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Asthma ;
>>Autoimmune thyroid disease ;
>>Inflammatory bowel disease ;
>>Systemic lupus erythematosus ;
>>Rheumatoid arthritis ;
>>Allograft rejection ;
>>Graft-versus-host disease ;
>>Viral myocarditis
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货号: YT6025
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

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