Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
产品列表
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TGFα Polyclonal Antibody
Human,Mouse,Rat,Monkey
WB,IHC,IF,ELISA
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Human TGF-α ELISA Kit
Human
ELISA
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Human TGF-α(Transforming Growth Factor α) ELISA Kit
Human
ELISA
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Total TGFα Cell-Based Colorimetric ELISA Kit
Human,Mouse,Rat
ELISA
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EGFR (PT0520R) PT® Rabbit mAb
Human,Mouse,Rat,
WB,IHC,IF,IP,ELISA
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EGFR (PTR2121) mouse mAb
Human,
IHC,WB,IF,ELISA
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EGFR Polyclonal Antibody
Human,Mouse,Rat
WB,IHC,IF,ELISA
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EGFR Polyclonal Antibody
Human,Mouse,Rat
WB,IHC,IF,ELISA
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EGFR (phospho Ser1070) Polyclonal Antibody
Human,Mouse,Rat
WB,IHC,IF,ELISA
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EGFR (phospho Thr693) Polyclonal Antibody
Human,Mouse,Rat
WB,IHC,IF,ELISA