CD146 Rabbit pAb
-YT8155
主要信息
Target
CD146
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IF, ELISA
MW
72kD (Calculated)
110kD (Observed)
Conjugate/Modification
Unmodified
货号: YT8155
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
72kD
实测条带
110kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
AA range:500-600
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特异性:
Endogenous
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基因名称:
MCAM MUC18
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蛋白名称:
CD146
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别名:
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12 ;
Melanoma cell adhesion molecule ;
Melanoma-associated antigen A32 ;
Melanoma-associated antigen MUC18 ;
S-endo 1 endothelial-associated antigen ;
CD antigen CD146)
Melanoma cell adhesion molecule ;
Melanoma-associated antigen A32 ;
Melanoma-associated antigen MUC18 ;
S-endo 1 endothelial-associated antigen ;
CD antigen CD146)
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背景:
function:Plays a role in cell adhesion , and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system , thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2 , and a transient increase in the intracellular calcium concentration. ,similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains. ,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains. ,tissue specificity:Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis. ,
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功能:
Function:Plays a role in cell adhesion , and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system , thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2 , and a transient increase in the intracellular calcium concentration. ,similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains. ,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains. ,tissue specificity:Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis. ,
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细胞定位:
Membrane
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文献引用（{{totalcount}}）
货号: YT8155
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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