NRAS/HRAS/KRAS

disease:Defects in NRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia.,disease:Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors.,enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).,function:Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.,online information:NRAS mutation db,online information:RAS proteins entry,PTM:Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.,similarity:Belongs to the small GTPase superfamily. Ras family.,subcellular location:Shuttles between the plasma membrane and the Golgi apparatus.,

endocytosis, apoptosis, cytoskeleton organization, intracellular signaling cascade, small GTPase mediated signal transduction, Ras protein signal transduction, aging, cell aging, behavior, learning or memory, learning, visual behavior, cell death, positive regulation of cell proliferation, visual learning, response to radiation, response to light stimulus, response to abiotic stimulus, positive regulation of signal transduction, membrane invagination, positive regulation of cell communication, regulation of cell death, programmed cell death, membrane organization, vesicle-mediated transport, death, actin filament-based process, actin cytoskeleton organization, regulation of neurological system process, regulation of synaptic transmission, GABAergic, regulation of Rac protein signal transduction, positive regulation of Rac protein signal transduction, regulation of cell proliferation, muscle cell differentiation, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, regulation of neuron apoptosis, negative regulation of neuron apoptosis, regulation of system process,regulation of Ras protein signal transduction, positive regulation of Ras protein signal transduction, regulation of synaptic plasticity, regulation of neuronal synaptic plasticity, regulation of long-term neuronal synaptic plasticity,regulation of synaptic transmission, neurological system process, cognition, regulation of small GTPase mediated signal transduction, positive regulation of small GTPase mediated signal transduction, striated muscle cell differentiation, regulation of transmission of nerve impulse, negative regulation of cell death,

Cell membrane ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus membrane ; Lipid-anchor . Shuttles between the plasma membrane and the Golgi apparatus. .