A-Raf Rabbit pAb
-YT0303
主要信息
Target
A-Raf
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
68kD (Observed)
Conjugate/Modification
Unmodified
货号: YT0303
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Note:For IHC,wesuggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note:For IHC,wesuggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
A-Raf Polyclonal Antibody detects endogenous levels of A-Raf protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
68kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human A-RAF. AA range:276-325
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特异性:
A-Raf Polyclonal Antibody detects endogenous levels of A-Raf protein.
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基因名称:
ARAF
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蛋白名称:
Serine/threonine-protein kinase A-Raf
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别名:
ARAF ;
ARAF1 ;
PKS ;
PKS2 ;
Serine/threonine-protein kinase A-Raf ;
Proto-oncogene A-Raf ;
Proto-oncogene A-Raf-1 ;
Proto-oncogene Pks
ARAF1 ;
PKS ;
PKS2 ;
Serine/threonine-protein kinase A-Raf ;
Proto-oncogene A-Raf ;
Proto-oncogene A-Raf-1 ;
Proto-oncogene Pks
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背景:
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012],
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 2 zinc ions per subunit.,Function:Involved in the transduction of mitogenic signals from the cell membrane to the nucleus.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RBD (Ras-binding) domain.,subunit:Interacts with TH1L/NELFD.,tissue specificity:Predominantly in urogenital tissues.,
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细胞定位:
intracellular,mitochondrion,cytosol,
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组织表达:
Predominantly in urogenital tissues.
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研究领域:
>>EGFR tyrosine kinase inhibitor resistance ;
>>Endocrine resistance ;
>>MAPK signaling pathway ;
>>ErbB signaling pathway ;
>>FoxO signaling pathway ;
>>Vascular smooth muscle contraction ;
>>Natural killer cell mediated cytotoxicity ;
>>Long-term potentiation ;
>>Serotonergic synapse ;
>>Long-term depression ;
>>Regulation of actin cytoskeleton ;
>>Insulin signaling pathway ;
>>Progesterone-mediated oocyte maturation ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Alcoholism ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Colorectal cancer ;
>>Renal cell carcinoma ;
>>Pancreatic cancer ;
>>Endometrial cancer ;
>>Glioma ;
>>Prostate cancer ;
>>Melanoma ;
>>Bladder cancer ;
>>Chronic myeloid leukemia ;
>>Acute myeloid leukemia ;
>>Non-small cell lung cancer ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer
>>Endocrine resistance ;
>>MAPK signaling pathway ;
>>ErbB signaling pathway ;
>>FoxO signaling pathway ;
>>Vascular smooth muscle contraction ;
>>Natural killer cell mediated cytotoxicity ;
>>Long-term potentiation ;
>>Serotonergic synapse ;
>>Long-term depression ;
>>Regulation of actin cytoskeleton ;
>>Insulin signaling pathway ;
>>Progesterone-mediated oocyte maturation ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Alcoholism ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Colorectal cancer ;
>>Renal cell carcinoma ;
>>Pancreatic cancer ;
>>Endometrial cancer ;
>>Glioma ;
>>Prostate cancer ;
>>Melanoma ;
>>Bladder cancer ;
>>Chronic myeloid leukemia ;
>>Acute myeloid leukemia ;
>>Non-small cell lung cancer ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer
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信号通路
Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton
Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity
Organismal Systems >> Endocrine system >> Insulin signaling pathway
Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: specific types >> Colorectal cancer
Human Diseases >> Cancer: specific types >> Pancreatic cancer
Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma
Human Diseases >> Cancer: specific types >> Gastric cancer
Human Diseases >> Cancer: specific types >> Glioma
Human Diseases >> Cancer: specific types >> Acute myeloid leukemia
Human Diseases >> Cancer: specific types >> Chronic myeloid leukemia
Human Diseases >> Cancer: specific types >> Melanoma
Human Diseases >> Cancer: specific types >> Renal cell carcinoma
Human Diseases >> Cancer: specific types >> Bladder cancer
Human Diseases >> Cancer: specific types >> Prostate cancer
Human Diseases >> Cancer: specific types >> Endometrial cancer
Human Diseases >> Cancer: specific types >> Breast cancer
Human Diseases >> Cancer: specific types >> Non-small cell lung cancer
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> ErbB signaling pathway
Environmental Information Processing >> Signal transduction >> FoxO signaling pathway
文献引用（{{totalcount}}）
货号: YT0303
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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