The antiserum was produced against synthesized peptide derived from human ATP6V1C2. AA range:121-170

V-ATPase C2 Polyclonal Antibody detects endogenous levels of V-ATPase C2 protein.

ATP6V1C2

V-type proton ATPase subunit C 2

ATP6V1C2 ;
V-type proton ATPase subunit C 2 ;
V-ATPase subunit C 2 ;
Vacuolar proton pump subunit C 2

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008],

Function:Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.,similarity:Belongs to the V-ATPase C subunit family.,subunit:V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).,tissue specificity:Kidney and placenta.,

vacuolar proton-transporting V-type ATPase, V1 domain,lysosomal membrane,cytosol,proton-transporting V-type ATPase, V1 domain,extracellular exosome,

Kidney and placenta.

>>Oxidative phosphorylation ;
>>Metabolic pathways ;
>>Phagosome ;
>>mTOR signaling pathway ;
>>Synaptic vesicle cycle ;
>>Collecting duct acid secretion ;
>>Vibrio cholerae infection ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Human papillomavirus infection ;
>>Rheumatoid arthritis