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Amphiregulin Rabbit pAb
-YT5644
主要信息
Target
Amphiregulin
Host Species
Rabbit
Reactivity
Human, Rat, Mouse,
Applications
WB, ELISA
MW
17kD (Observed)
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Amphiregulin Polyclonal Antibody detects endogenous levels of Amphiregulin protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
17kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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YM3028
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from the Internal region of human AREG/AREGB. AA range:91-140
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特异性:
Amphiregulin Polyclonal Antibody detects endogenous levels of Amphiregulin protein.
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基因名称:
AREG/AREGB
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蛋白名称:
Amphiregulin
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别名:
AREG ;
SDGF ;
AREGB ;
Amphiregulin ;
AR ;
Colorectum cell-derived growth factor ;
CRDGF
SDGF ;
AREGB ;
Amphiregulin ;
AR ;
Colorectum cell-derived growth factor ;
CRDGF
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背景:
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014],
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功能:
Function:Bifunctional growth-modulating glycoprotein. Inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells.,induction:By phorbol 12-myristate 13-acetate (PMA).,miscellaneous:AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.,similarity:Belongs to the amphiregulin family.,similarity:Contains 1 EGF-like domain.,subunit:The immature precursor interacts with CNIH.,
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细胞定位:
Membrane; Single-pass membrane protein.
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组织表达:
Brain,Pooled,
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研究领域:
>>MAPK signaling pathway ;
>>ErbB signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Hippo signaling pathway ;
>>Colorectal cancer
>>ErbB signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Hippo signaling pathway ;
>>Colorectal cancer
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信号通路
Human Diseases >> Cancer: specific types >> Colorectal cancer Environmental Information Processing >> Signal transduction >> MAPK signaling pathway Environmental Information Processing >> Signal transduction >> ErbB signaling pathway Environmental Information Processing >> Signal transduction >> Hippo signaling pathway Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
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