主要信息
Target
CA IX
Host Species
Mouse
Reactivity
Human,
Applications
IHC
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
Ready to use for IHC
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
特异性
This antibody detects endogenous levels of CA IX protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
2°C to 8°C/1 year
修饰
Unmodified
克隆性
Monoclonal
克隆号
PTR2373
同种型
IgG
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抗原&靶点信息
免疫原:
Recombinant protein
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特异性:
This antibody detects endogenous levels of CA IX protein.
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基因名称:
CA9
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蛋白名称:
Carbonic anhydrase 9
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别名:
G250 ;
MN ;
Carbonic anhydrase 9 ;
Carbonate dehydratase IX ;
Carbonic anhydrase IX ;
CA-IX ;
CAIX ;
Membrane antigen MN ;
P54/58N ;
Renal cell carcinoma-associated antigen G250 ;
RCC-associated antigen G250 ;
pMW1
MN ;
Carbonic anhydrase 9 ;
Carbonate dehydratase IX ;
Carbonic anhydrase IX ;
CA-IX ;
CAIX ;
Membrane antigen MN ;
P54/58N ;
Renal cell carcinoma-associated antigen G250 ;
RCC-associated antigen G250 ;
pMW1
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功能:
Catalytic activity:H(2)CO(3) = CO(2) + H(2)O.,cofactor:Zinc.,Function:Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.,induction:By hypoxia.,PTM:Asn-346 bears high-mannose type glycan structures.,similarity:Belongs to the alpha-carbonic anhydrase family.,subcellular location:Found on the surface microvilli and in the nucleus, particularly in nucleolus.,subunit:Forms oligomers linked by disulfide bonds.,tissue specificity:Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.,
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细胞定位:
Membranous
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组织表达:
Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.
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研究领域:
>>Nitrogen metabolism ;
>>Metabolic pathways
>>Metabolic pathways
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