Synthesized peptide derived from part region of human protein

GNA11 Polyclonal Antibody detects endogenous levels of protein.

GNA11 GA11

Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha)

The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013],

Function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.,similarity:Belongs to the G-alpha family. G(q) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.,

Cell membrane ; Lipid-anchor . Cytoplasm . In testicular cells, expressed exclusively in the cytoplasm.

Expressed in testis.

>>Calcium signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>Vascular smooth muscle contraction ;
>>Gap junction ;
>>Cholinergic synapse ;
>>Long-term depression ;
>>Insulin secretion ;
>>GnRH signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Cortisol synthesis and secretion ;
>>Parathyroid hormone synthesis, secretion and action ;
>>GnRH secretion ;
>>Cushing syndrome ;
>>Growth hormone synthesis, secretion and action ;
>>Chagas disease ;
>>Amoebiasis ;
>>Human cytomegalovirus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Pathways in cancer