Synthesized peptide derived from human DOCK4 AA range: 533-583

This antibody detects endogenous levels of DOCK4 at Human/Mouse

DOCK4 KIAA0716

DOCK4

This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008],

Disease:Defects in DOCK4 are involved in the cause of some cancers, which are probably due to lack of Rap1 activation.,Domain:The DHR-2 domain probably mediates the GEF activity.,Function:Involved in regulation of adherens junction between cells. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.,miscellaneous:Injection of wild-type protein suppresses tumor invasion in osteosarcoma mouse cell lines while it is not the case with the Leu-1718 variant.,similarity:Belongs to the DOCK family.,similarity:Contains 1 DHR-1 (CZH-1) domain.,similarity:Contains 1 DHR-2 (CZH-2) domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1.,tissue specificity:Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.,

Cell membrane . Cell projection . Cytoplasm, cytosol . Colocalizes with EPHA2, RHOG and CTTN/cortactin at the tip of protrusions in migrating cells. .

Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary. ; [Isoform 2]: May be specifically expressed in the brain and eye.

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