The antiserum was produced against synthesized peptide derived from human ADCY1. AA range:231-280

A Cyclase I Polyclonal Antibody detects endogenous levels of A Cyclase I protein.

ADCY1

Adenylate cyclase type 1

ADCY1 ;
Adenylate cyclase type 1 ;
ATP pyrophosphate-lyase 1 ;
Adenylate cyclase type I ;
Adenylyl cyclase 1 ;
Ca ;
2+ ;
/calmodulin-activated adenylyl cyclase

This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],

Catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex.,Function:This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,tissue specificity:Brain, retina and adrenal medulla.,

Membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasm . Membrane raft . Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia. .

Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Brain, retina and adrenal medulla.

>>Purine metabolism ;
>>Metabolic pathways ;
>>Endocrine resistance ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Oocyte meiosis ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Adrenergic signaling in cardiomyocytes ;
>>Vascular smooth muscle contraction ;
>>Apelin signaling pathway ;
>>Gap junction ;
>>Platelet activation ;
>>Circadian entrainment ;
>>Thermogenesis ;
>>Long-term potentiation ;
>>Retrograde endocannabinoid signaling ;
>>Glutamatergic synapse ;
>>Cholinergic synapse ;
>>GABAergic synapse ;
>>Inflammatory mediator regulation of TRP channels ;
>>Insulin secretion ;
>>GnRH signaling pathway ;
>>Ovarian steroidogenesis ;
>>Progesterone-mediated oocyte maturation ;
>>Estrogen signaling pathway ;
>>Melanogenesis ;
>>Thyroid hormone synthesis ;
>>Oxytocin signaling pathway ;
>>Regulation of lipolysis in adipocytes ;
>>Aldosterone synthesis and secretion ;
>>Relaxin signaling pathway ;
>>Cortisol synthesis and secretion ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Cushing syndrome ;
>>Growth hormone synthesis, secretion and action ;
>>Salivary secretion ;
>>Gastric acid secretion ;
>>Pancreatic secretion ;
>>Bile secretion ;
>>Morphine addiction ;
>>Chagas disease ;
>>Amoebiasis ;
>>Human cytomegalovirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Pathways in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Dilated cardiomyopathy