The antiserum was produced against synthesized peptide derived from human RAPGEF5. AA range:431-480

Repac Polyclonal Antibody detects endogenous levels of Repac protein.

RAPGEF5

Rap guanine nucleotide exchange factor 5

RAPGEF5 ;
GFR ;
KIAA0277 ;
MRGEF ;
Rap guanine nucleotide exchange factor 5 ;
Guanine nucleotide exchange factor for Rap1 ;
M-Ras-regulated Rap GEF ;
MR-GEF ;
Related to Epac ;
Repac

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008],

Function:Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,tissue specificity:Widely expressed with highest levels in brain.,

Nucleus.

Widely expressed with highest levels in brain.

>>Ras signaling pathway ;
>>Rap1 signaling pathway