This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012],
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功能:
Function:Potential mitochondrial transporter. May play a role in apoptosis.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 2 Solcar repeats.,subunit:Interacts with PSEN1.,tissue specificity:Widely expressed with a predominant expression in brain.,
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细胞定位:
Mitochondrion outer membrane ; Multi-pass membrane protein .
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组织表达:
Widely expressed with a predominant expression in brain.