There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
产品列表
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VEGFA (PT0522R) PT® Rabbit mAb
Human,Mouse,Rat,
WB,IHC,IF,IP,ELISA
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VEGF-A (PT0865) Mouse mAb
Human,Mouse,Rat,
WB,IF,ELISA
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VEGF Rabbit pAb
Human,Rat,Mouse
IF,WB,IHC,ELISA
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VEGF-A Rabbit pAb
Human,Mouse,Rat,Pig,Rabbit
WB,IF,IHC,ELISA
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Murine VEGF ELISA Kit
Mouse
ELISA
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Rat VEGF ELISA Kit
Rat
ELISA
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Human VEGF-A(Vascular Endothelial Cell Growth Factor A ) ELISA Kit
Human
ELISA
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Mouse VEGF-A(Vascular Endothelial Cell Growth Factor A) ELISA Kit
Mouse
ELISA
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Rat VEGF-A(Vascular Endothelial Cell Growth Factor A ) ELISA Kit
Rat
ELISA
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Flk-1/VEGFR2 Rabbit pAb
Human,Mouse,Fish
WB,IHC,IF,ELISA