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VEGF signaling pathway
There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
产品列表
    货号
    产品
    反应
    应用
  • VEGFA (PT0522R) PT® Rabbit mAb
    Human,Mouse,Rat,
    WB,IHC,IF,IP,ELISA
  • VEGF-A (PT0865) Mouse mAb
    Human,Mouse,Rat,
    WB,IF,ELISA
  • VEGF Rabbit pAb
    Human,Rat,Mouse
    IF,WB,IHC,ELISA
  • VEGF-A Rabbit pAb
    Human,Mouse,Rat,Pig,Rabbit
    WB,IF,IHC,ELISA
  • Murine VEGF ELISA Kit
    Mouse
    ELISA
  • Rat VEGF ELISA Kit
    Rat
    ELISA
  • Human VEGF-A(Vascular Endothelial Cell Growth Factor A ) ELISA Kit
    Human
    ELISA
  • Mouse VEGF-A(Vascular Endothelial Cell Growth Factor A) ELISA Kit
    Mouse
    ELISA
  • Rat VEGF-A(Vascular Endothelial Cell Growth Factor A ) ELISA Kit
    Rat
    ELISA
  • Flk-1/VEGFR2 Rabbit pAb
    Human,Mouse,Fish
    WB,IHC,IF,ELISA
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