Synthesized peptide derived from human CD105 AA range:400-500

This antibody detects endogenous levels of CD105(Endoglin)

ENG

CD105 (Endoglin)

AI528660 ;
AI662476 ;
CD 105 ;
CD105 ;
CD105 antigen ;
EGLN_HUMAN ;
END ;
Endoglin ;
Eng ;
FLJ41744 ;
HHT1 ;
ORW ;
ORW1 ;
Osler Rendu Weber syndrome 1 ;
RP11 228B15.2 ;
S endoglin ;
S-endoglin ;
SN6

disease:Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300 , 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1) . HHT1 is an autosomal dominant multisystemic vascular dysplasia , characterized by recurrent epistaxis , muco-cutaneous telangiectases , gastro-intestinal hemorrhage , and pulmonary (PAVM) , cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed , there is an important clinical heterogeneity. ,function:Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. ,subunit:Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It is able to bind TGF-beta 1 , and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. ,tissue specificity:Endoglin is restricted to endothelial cells in all tissues except bone marrow. ,

Cell membrane ; Single-pass type I membrane protein .