Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

EGF

Pro-epidermal growth factor

EGF ;
Pro-epidermal growth factor ;
EGF

disease:Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4) [MIM:611718]; also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes.,function:EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.,online information:Epidermal growth factor entry,similarity:Contains 9 EGF-like domains.,similarity:Contains 9 LDL-receptor class B repeats.,tissue specificity:Expressed in kidney, salivary gland, cerebrum and prostate.,

MAPKKK cascade, activation of MAPKK activity, angiogenesis, blood vessel development, morphogenesis of a branching structure, regulation of protein amino acid phosphorylation, vasculature development, DNA metabolic process, DNA replication, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process,regulation of mitosis, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, epidermal growth factor receptor signaling pathway, regulation of epidermal growth factor receptor activity, intracellular signaling cascade, protein kinase cascade, regulation of mitotic cell cycle, positive regulation of cell proliferation, positive regulation of signal transduction, regulation of receptor activity, positive regulation of phosphorus metabolic process, regulation of cell cycle process, positive regulation of organelle organization, positive regulation of cell communication, phosphorylation,peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, regulation of phosphate metabolic process,regulation of granule cell precursor proliferation, positive regulation of granule cell precursor proliferation, regulation of protein modification process, activation of protein kinase activity, regulation of cellular protein metabolic process,regulation of protein localization, regulation of organelle organization, positive regulation of kinase activity, tube morphogenesis, tube development, regulation of epidermal growth factor receptor signaling pathway, regulation of cell proliferation, regulation of phosphorylation, positive regulation of phosphorylation, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of kinase activity,positive regulation of molecular function, positive regulation of epidermal growth factor receptor activity, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of cell cycle, positive regulation of mitosis, regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of phosphate metabolic process, blood vessel morphogenesis, branching morphogenesis of a tube, regulation of protein secretion, regulation of peptidyl-tyrosine phosphorylation, regulation of secretion, negative regulation of secretion,negative regulation of transport, positive regulation of cellular component organization, regulation of phosphorus metabolic process, regulation of protein transport, regulation of transferase activity, positive regulation of transferase activity, regulation of cell cycle, regulation of nuclear division, positive regulation of nuclear division, regulation of nervous system development, regulation of cellular localization, regulation of establishment of protein localization,

Membrane; Single-pass type I membrane protein.

Expressed in kidney, salivary gland, cerebrum and prostate.